剧情简介：

Set in the 22nd century in New London, Inspector Beth Lestrade of New Scotland Yard is chasing grotesquely deformed French rogue geneticist Martin Fenwick, when she realizes that his companion is none other than the 19th century criminal mastermind, Professor James Moriarty (this is not the original Moriarty but in fact his clone, created from cells taken from his corpse, which Holmes had buried in a Swiss ice cave). Famous biologist Sir Evan Hargreaves (who looks just like Doyle) has just invented cellular rejuvenation. Beth knows that Holmes survived and actually lived to a ripe old age, and further knows that his corpse is preserved in a glass-walled, honey-filled coffin in the basement of New Scotland Yard (this may be both a reference to the legend that Alexander the Great＇s body was preserved in honey, which does not rot, and also to the fact that, as stated in the original stories by Doyle, Holmes became a beekeeper once he retired). She takes the body from the basement and delivers it to Sir Evan. The biologist then uses his cellular rejuvenation technique to return life and youth to Holmes＇s body, so that the detective can combat Moriarty.